Jonas Brothers Rock From the Rooftop in Inspiring Video For Bouncy Single ‘I Can’t Lose’

The Jonas Brothers dropped the latest preview of their upcoming seventh studio album, Greetings From Your Hometown, on Wednesday morning (July 16). The bouncy, ready for hot fun in the summertime single “I Can’t Lose” is an homage to a love that makes everything feel right, even when things are going wrong.

“I woke up late, missed the alarm, can’t find the keys to my car/ What do you know? Power went out, I’m getting dressed in the dark/ Finally got out the door, but on the way, they cancelled my flight/ Nothing’s working anymore, feels like I’m losing my mind,” Joe Jonas sings on the first verse of the bubbling tune that features Joe teaming with Nick on the keening chorus of the track that will be featured on the LP due out on Aug. 8.

“I can’t lose when I’m with you/ Oh-oh, you give me everything, everything that I need, everything that I need to keep smiling through-ooh-ooh/ I can’t lose when I’m with you/ Oh-oh, made out of magic and I gotta have it, I made it a habit to keep smiling through-ooh-ooh,” they sing on the soaring refrain.

The positive energy carries over into the performance video for the single, which mixes footage of the Brothers singing on a New York rooftop for a group of select fans with images of cancer survivors celebrating the end of treatment and receiving loving support from their families. The song was first featured as the official anthem of ESPN’s Sunday Night Baseball coverage and the uplifting video debuted in partnership with Mastercard in support of Stand Up To Cancer during Tuesday night’s (July 15) 2025 MLB All-Star game.

“We debuted ‘I Can’t Lose’ – a song about love, strength, and showing up for the people you love. Dedicated to all of those who Stand Up To Cancer,” the band said in a statement. “Teaming up with Mastercard to uplift fans who’ve found hope and healing in our music means so much to us. ‘I Can’t Lose’ is a song we hope can carry different meanings for everyone who hears it and, for those who need it, a reminder of their own strength.”

“I Can’t Lose” follows the trio’s most recent single, the Bee Gees-interpolating disco pop single “No Time To Talk.” So far, they’ve also previewed the album with the songs “Love Me to Heaven” and the Marshmello collab “Slow Motion.”

The JoBros will kick off their 2025 JONAS20: Greetings From Your Hometown tour on Aug. 10 at MetLife Stadium in East Rutherford, N.J.

Check out the “I Can’t Lose” video below.