The singer filled in for Kelly Clarkson, who was out sick with COVID for the taping.
"Stupid Love" was the lead single off Gaga's 2020 album, 'Chromatica.'
The singer took a walk on the dark side for her cover of the rock's band's breakthrough hit.
"It was such a huge part of me finding my own identity and embracing my queerness," the Disney Channel alum said of her breakout single.
The singer crooned the standard with just a piano and guitar.
"They're hilarious, they're pure and they're professional," she said of her Only Murders in the Building castmates.
Or maybe you think of "How Do I Live" as a LeAnn Rimes song instead, since her version was the higher-charting, peaking at No. 2 on the Billboard Hot 100.
The talk show host shared the stage with a saxophonist for the number.
The singer channeled the 1970s with one of the rock band's two No. 1 hits on the Hot 100.
The Queen of Covers puts her spin on 2018's "Let Me Down Slowly."