The reggaeton stars sang their new track for the first time on television.
The trio will play after Blink-182's headlining set.
Before kicking off the live broadcast, stars such as Becky G, Anuel AA, David Bisbal, Chiquis and Pepe Aguilar walked the red carpet.
The top nominees of the night are Karol G, Bad Bunny, Daddy Yankee and Becky G.
On the five year anniversary of the producer's death, we run down 15 of the tracks that cement his legacy as one of the greatest to ever do it.
The musical's leading lady ranks the pop icons best both in and out of her show.
"Let's keep showing up for each other even when it's hard," the model wrote.
In the statement, the two parties call E-40's ejection from the Kings & Warriors April 15 game "an unfortunate misunderstanding."
The two space explorers are currently living aboard the International Space Station.
"Who could say they got high with Snoop Dogg? That's like a lifetime thing," the "I'm Good (Blue)" singer says.
