The Mexican-American band performed their Billboard chart-topping hit.
"To be an agent of change you just have to differentiate what is right from what is wrong," said the Colombian superstar.
The new, bilingual version is part of Moly's new album, "Metamorfosis."
Camila performed "Fugitivos," the trio's first single in a decade.
Shakira was the big winner of the night taking home eight awards.
Genre staples Pavel Núñez, Fernando Villalona, La Materialista, Jandy Ventura and Ilegales came together at the 20th anniversary of the awards ceremony.
Ángela Aguilar, Boza, Eslabon Armado, Conexión Divina and Camila were among the superstars to walk the red carpet.
"Me gusta andar con la plebada, puras fresitas operadas," JOP sang at the 20th anniversary of the award ceremony.
Angel & Khriz, R.K.M & Ken-Y, Alexis & Fido, Zion & Lennox and more make a statement as the bold powerhouse duos of reggaetón.
The Dallas-born siblings are set to drop new music soon.
