The R&B legends will set up shop at the Mandalay Bay Resort at the House of Blues beginning in March.
The band will return to the Dolby Live theater for a 16-show run.
“Sing with us, for Shane McGowan,” Bono told fans at Las Vegas’ Sphere.
The British star previously said she was "literally borderline alcoholic" in her 20s.
“He’s probably the best comedic character of all time,” the British star said.
The Irish rockers will launch their Sin City residency on Sept. 29.
The new shows will begin in March.
The singer stopped her residency show on Saturday to ask why security were so focused on a young man standing up and singing during her performance.
“When I sing 'everybody on mute,'" you have to be f---ing quiet," the superstar singer said.
"You did amazing," the pop star told River Rose after their performance of "Heartbeat Song."
