The San Bernardino event will also star Kodak Black, Chino Pacas, Sexy Red, Luis R. Conriquez, Xavi, Los Rieleros del Norte, Bone Thugs, Too Short & more.
Thomas will continue to serve as VIBE's editor-at-large, as well as vice president of culture and media at PMC.
The Queens rapper's monster hit reached the milestone 12 years after its initial release.
The Salt-N-Pepa legend's keynote was a highlight at the ninth annual State of Music in Media Conference in Hollywood.
The awards dinner and gala in October will also commemorate the 50th anniversary of hip-hop.
Cheryl “Salt” James (Salt of Salt-N-Pepa) will keynote the event, sponsored by the Guild of Music Supervisors.
"Black Panther: Wakanda Forever" won outstanding motion picture, just as the original "Black Panther" did four years ago.
