The commentator's thoughts came in response to a post by the singer's mother, Tina Knowles.
"You're so irrelevant," the conservative pundit fired back.
Cardi's comments came after Owens said that NSFW sites are a "psychological weapon intended to weaken our men."
We've compiled the full timeline of Cardi vs. Candace.
The conservative commentator has picked a fight or two with several artists over the last few years.
"The point is about acceptance and love," one fan wrote in response to the conservative commentator.
"Respectfully back the f--- off," the 19-year-old pop singer and dancer wrote.
Kanye is facing backlash after continuing to spread hateful messages online.
