The news comes after an evacuation notice was issued to attendees earlier Friday.
The festival pioneer was also a creative force behind Outside Lands and Clusterfest.
"Can’t wait to grow wings and fly with all of you," said vocalist and guitarist Stu Mackenzie.
The June 13-16 event will also feature sets from Megan Thee Stallion, Cage the Elephant, Maggie Rogers and Diplo.
The performance marked the close of this year's festival.
The four-night extravaganza commences Thursday, June 15.
The festival assured attendees that "The Farm will remain a sanctuary for those freedoms."
The electronic duo's top billing at Bonnaroo and Governor's Ball 2023 is the result of two hugely successful tours, a dedicated fanbase and 10 years of strategy.
A brief delay in the Coachella announcement this year left other festivals scrambling, demonstrating the interconnectedness of the entire ecosystem.
This year’s Bonnaroo lineup just dropped and it’s looking pretty, pretty nice. Among the EDM acts, Zeds Dead and Liquid Stranger headline Thursday night, typically the “soft open” for the main festival weekend though no less important. GRiZ, Subtronics, Peekaboo, Apashe, Boogie T b2b Dirt
